Salts, Cocrystals, and Ionic Cocrystals of a “Simple” Tautomeric Compound
نویسندگان
چکیده
منابع مشابه
Improving Lithium Therapeutics by Crystal Engineering of Novel Ionic Cocrystals
Current United States Food and Drug Administration (FDA)-approved lithium salts are plagued with a narrow therapeutic window. Recent attempts to find alternative drugs have identified new chemical entities, but lithium's polypharmacological mechanisms for treating neuropsychiatric disorders are highly debated and are not yet matched. Thus, re-engineering current lithium solid forms in order to ...
متن کاملPharmaceutical Cocrystals: An Overview
In the last few years, a large number of drugs have been discovered with low aqueous solubility. Among these recently discovered drugs, about 60-70% of the compounds are related to the BCS Class II (low solubility/high permeability) and IV (low solubility/ low permeability)[1,2]. Many active pharmaceutical ingredients (APIs) have not been developed in formulations due to low aqueous solubility,...
متن کاملSolvates, Salts, and Cocrystals: A Proposal for a Feasible Classification System
The design of pharmaceutical cocrystals has initiated widespread debate on the classification of cocrystals. Current attempts to classify multicomponent crystals suffer from ambiguity, which has led to inconsistent definitions for cocrystals and for multicomponent crystals in general. Inspired by the work of Aitipamula et al. (Cryst. Growth Des. 2012, 12, 2147−2152), we present a feasible class...
متن کاملNon-Covalent Derivatives: Cocrystals and Eutectics.
Non-covalent derivatives (NCDs) are formed by incorporating one (or more) coformer molecule(s) into the matrix of a parent molecule via non-covalent forces. These forces can include ionic forces, Van der Waals forces, hydrogen bonding, lipophilic-lipophilic interactions and pi-pi interactions. NCDs, in both cocrystal and eutectic forms, possess properties that are unique to their supramolecular...
متن کاملRelationship Between Crystal Structure and Mechanical Properties in Cocrystals and Salts of Paracetamol
To my family and To the protectors of human dignity in the city of Kobanê in Rojava and in Bashur. Abstract Oral tablets are convenient and widely administered drug dosage forms. The mechanical properties of a drug substance such as plasticity, ability to cohere into compacts and friction/adhesion are important in the development of a tablet formulation. Crystal engineering is an interesting an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Crystal Growth & Design
سال: 2018
ISSN: 1528-7483,1528-7505
DOI: 10.1021/acs.cgd.8b01159